The Lancet Global Health: The Vaccine Trust Framework

Features
Written By Charlotte Vangsgaard

AUGUST 20, 2025

Our paper published in Lancet Global Health, explaining how ReD Associates built a groundbreaking tool for understanding and building trust to drive vaccine uptake based on research in Kenya, Nigeria and Pakistan, and surveys of over 7,000 caregivers.

The Vaccine Trust Framework reflects communities’ lived experiences with health and vaccination systems. It presents a way of understanding and quantifying trust, while providing a path to action for decision-makers, with data linking trust and vaccine uptake. With vaccine trust declining across the world, the Vaccine Trust Framework has the potential to help shape the future of vaccine demand-building work across the global health landscape.

“The Vaccine Trust Framework, established through synthesis of ethnographic research, contains four interlinked domains—health system promise, health system delivery, vaccine promise, and vaccine delivery—and 15 measurable dimensions. Survey data were collected from 3670 participants in Kenya and 3734 in Pakistan. Trust was observed to influence vaccine behaviour and intentions, which was further supported by associations between quantitative trust scores and vaccination status across the studied vaccines. Regional trust variation was observed within Kenya and Pakistan, with patterns matching qualitative findings on the perceptions of local vaccine and health systems.”

Read the full article on the Lancet or watch our video below for more.

Charlotte Vangsgaard

Charlotte is focused on driving social impact in both nonprofit and commercial organizations. Across her diverse set of clients from iconic luxury goods to healthcare, Charlotte specializes in deriving commercial value from a strategy aligned around social possibilities. Today she is also spearheading change management strategies at some of the world’s largest foundations and corporations. All of her client work—as well as her most recent writing—explores innovative ways to apply social science theory to business problems.

Before joining ReD, Charlotte drove projects on poverty alleviation and economic development for the United Nations Development Programme in Cairo and Algiers before moving on to work for the Danish Government and the International Center for Corporate Accountability. She holds an MBA in International Business and Marketing and a Masters in Political Science.

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